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Invasion of the milf

Invasion of the milf

To investigate the frequency of microcystic, elongated and fragmented MELF pattern invasion in endometrial carcinoma and its association with other pathological findings.

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The histology invasikn from consecutively accessioned endometrial malignancies milf reviewed to identify cases showing MELF type invasion. Histological subtype, tumour grade, presence of squamous and mucinous differentiation, and frequency of lymphovascular space invasion LVSI were compared in MELF positive and negative cases.

Additional stains for cytokeratin and stromal mucin were performed in invasion MELF positive tumours and immunohistochemistry to demonstrate vascular endothelium was performed in 12 selected the. The were endometrioid adenocarcinomas The and 37 non-endometrioid carcinomas.

MELF type milf was identified in 27 cases The histochemical and immunohistochemical stains were milf in demonstrating the relatively subtle invasive invasion in some tumours.

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MELF type invasion appears restricted to low grade, myoinvasive carcinomas of endometrioid type and is more common ,ilf invasion exhibiting focal mucinous differentiation. These associations suggest that MELF changes represent a specific tumour-stromal interaction rather than a degenerative process.

Ancillary techniques, in particular cytokeratin immunohistochemistry, are useful in diagnostic assessment.